Journal
CANCERS
Volume 6, Issue 2, Pages 813-828Publisher
MDPI AG
DOI: 10.3390/cancers6020813
Keywords
tumor angiogenesis; tumor microcirculation; tumor hypoxia; hypoxia-inducible factor (HIF); radioresistance; hypoxia modifiers
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Funding
- HelmholtzZentrum munchen (Clinical Cooperation Group. Innate Immunity in Tumor Biology.)
- Deutsche Forschungsgemeinschaft [SFB 824/2]
- Cluster of Excellence
- Munich-Centre for Advanced Photonics (MAP)
- INST [95/980-1]
- BMBF (Kompetenzverbund Strahlenforschung) [03NUK007E, 01EX1021C]
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Newly formed microvessels in most solid tumors show an abnormal morphology and thus do not fulfil the metabolic demands of the growing tumor mass. Due to the chaotic and heterogeneous tumor microcirculation, a hostile tumor microenvironment develops, that is characterized inter alia by local hypoxia, which in turn can stimulate the HIF-system. The latter can lead to tumor progression and may be involved in hypoxia-mediated radioresistance of tumor cells. Herein, cellular and molecular mechanisms in tumor angiogenesis are discussed that, among others, might impact hypoxia-related radioresistance.
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