Journal
TRANSLATIONAL NEURODEGENERATION
Volume 2, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/2047-9158-2-15
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Funding
- Canadian Institutes of Health Research (CIHR) [CCI-117952]
- Chinese Scholarship Council award
- UBC 4YF Scholarship
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Presenilins (PSs) are the catalytic core of gamma-secretase complex. However, the mechanism of FAD-associated PS mutations in AD pathogenesis still remains elusive. Here we review the general biology and mechanism of gamma-secretase and focus on the catalytic components - presenilins and their biological functions and contributions to the AD pathogenesis. The functions of presenilins are divided into gamma-secretase dependent and gamma-secretase independent ones. The gamma-secretase dependent functions of presenilins are exemplified by the sequential cleavages in the processing of APP and Notch; the gamma-secretase independent functions of presenilins include stabilizing beta-catenin in Wnt signaling pathway, regulating calcium homeostasis and their interaction with synaptic transmission.
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