Journal
ACTA PHARMACEUTICA SINICA B
Volume 4, Issue 4, Pages 258-265Publisher
INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
DOI: 10.1016/j.apsb.2014.06.012
Keywords
RNA; Antibiotics; Drug targeting; Bacteria
Categories
Funding
- National Natural Science Foundation of China [81371851, 81071316, 81271882, 81301394]
- New Century Excellent Talents in Universities [NCET-11-0703]
- National Megaprojects for Key Infectious Diseases [2008ZX10003-006]
- Southwestern University [kb2010017, ky2011003]
- Fundamental Research Fund for Central Universities [XDJK2011D006, XDJK2012D011, XDJK2012D007, XDJK2013D003, XDJK2014D040]
- Natural Science Foundation Project of CQ CSTC [CSTC 2010BB5002]
- Chongqing Municipal Committee of Education for Postgraduate Excellence Program [YJG123104]
- Undergraduate Teaching Reform Program [2013JY201]
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RNAs have diverse structures that include bulges and internal loops able to form tertiary contacts or serve as ligand binding sites. The recent increase in structural and functional information related to RNAs has put them in the limelight as a drug target for small molecule therapy. In addition, the recognition of the marked difference between prokaryotic and eukaryotic rRNA has led to the development of antibiotics that specifically target bacterial rRNA, reduce protein translation and thereby inhibit bacterial growth. To facilitate the development of new antibiotics targeting RNA, we here review the literature concerning such antibiotics, mRNA, riboswitch and tRNA and the key methodologies used for their screening. (C) 2014 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
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