Journal
EBIOMEDICINE
Volume 34, Issue -, Pages 231-242Publisher
ELSEVIER
DOI: 10.1016/j.ebiom.2018.07.015
Keywords
Extracellular vesicles; Adipose-derived stem cells; Regeneration; Liver failure; LncRNA
Funding
- key medical innovation projects of the Nanjing Military [14ZX01]
- Chinese foundation for hepatitis prevention and control - TianQing liver disease research fund subject [TQGB20150104]
- National Major Scientific and Technological Special Project for 'Significant New Drugs Development' [SQ2018ZX090201]
- Fundamental Research Fund for Central Universities [1500219107]
- National Natural Science Foundation of China [81461138037, 31471029, 31671055]
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It has previously been reported that human adipose-derived stem cells (hASCs) can promote the regeneration of damaged tissues in rats with liver failure through a 'paracrine effect'. Here we demonstrate a therapeutic effect of hASCs derived Extracellular Vesicles (EVs) on rat models with acute liver failure, as shown by the improvement of the survival rate by >70% compared to controls. Gene sequencing of rat liver revealed an increase in human long-chain non-coding RNA (lncRNA) H19 after hASC-derived EVs transplantation. When the H19 coding sequence was silenced in hASCs and EVs were then collected for treatment of rats with liver failure, we saw a decrease in the survival rate to 40%, compared to treatment with EVs generated from non-silenced hASCs. These data indicate that lncRNA H19 may be a potential therapeutic target for the treatment of liver failure. (c) 2018 The Authors. Published by Elsevier B.V.
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