Journal
ACS SENSORS
Volume 3, Issue 9, Pages 1863-1869Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acssensors.8b00685
Keywords
triple-emission; fluorescent probe; thiols; discriminatory; imaging
Funding
- National Natural Science Foundation of China [U1608222]
- Special Fund for Agro-scientific Research in the Public Interest of China [201503108]
- State Key Laboratory of Chemo/Biosensing and Chemometrics [2016005]
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Thiols, such as cysteine (Cys), homocysteine (Hcy), glutathione (GSH), hydrogen sulfide (H2S), and thiophenol are metabolically correlated with each other via redox reactions. As a result of the similarity of chemical properties between Cys, Hcy, GSH, H2S, and thiophenol, it is very challenging to develop an effective methodology to differentiate them. In this work, a triple-emission fluorescent probe, NCQ, was reported for the simultaneous detection of Cys/Hcy, GSH/H2S, and thiophenol with high sensitivity and selectivity. The solution of NCQ displayed distinct fluorescent signals toward Cys/Hcy, GSH/H2S, and thiophenol: blue and green for Cys/Hcy, blue for GSH/H2S, blue and red for thiophenol. Through the blue-green-red emission color combination, Cys/Hcy, GSH/H2S, and thiophenol could be discriminatively detected in solution and in living cells.
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