Journal
MOLECULAR IMAGING
Volume 9, Issue 3, Pages 117-127Publisher
SAGE PUBLICATIONS INC
DOI: 10.2310/7290.2010.00022
Keywords
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Funding
- National Institutes of Health [R01 EB009066, R01 EB008733]
- NIH Roadmap for Medical Research [R21EB005325]
- University of North Carolina Lineberger Cancer Center
- Scientific Advisory Board for Targeson, LLC
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R21EB005325, R01EB009066, R01EB008733] Funding Source: NIH RePORTER
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Ultrasound imaging has long demonstrated utility in the study and measurement of anatomic features and noninvasive observation of blood flow. Within the last decade, advances in molecular biology and contrast agents have allowed researchers to use ultrasound to detect changes in the expression of molecular markers on the vascular endothelium and other intravascular targets. This new technology, referred to as ultrasonic molecular imaging, is still in its infancy. However, in preclinical studies, ultrasonic molecular imaging has shown promise in assessing angiogenesis, inflammation, and thrombus. In this review, we discuss recent advances in microbubble-type contrast agent development, ultrasound technology, and signal processing strategies that have the potential to substantially improve the capabilities and utility of ultrasonic molecular imaging.
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