Journal
FRONTIERS IN PEDIATRICS
Volume 2, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2014.00108
Keywords
IL-1; rIL-RA; perinatal brain injury; IL-1beta; Kineret
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Funding
- EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT [K08HD073315] Funding Source: NIH RePORTER
- NICHD NIH HHS [K08 HD073315] Funding Source: Medline
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Interleukin-1 (IL-1) is a potent inflammatory cytokine that can be produced by a variety of cell types throughout the body. While IL-1 is a central mediator of inflammation and response to infection, the role of IL-1 signaling in adult and pediatric brain injury is becoming increasingly clear. Although the mechanisms of IL-1 expression are largely understood, the downstream effects and contributions to excitotoxicity and oxidative stress are poorly defined. Here, we present a review of mechanisms of IL-1 signaling with a focus on the role of IL-1 in perinatal brain injury. We highlight research models of perinatal brain injury and the use of interleukin-1receptor antagonist (IL-1 RA) as an agent of therapeutic potential in preventing perinatal brain injury due to exposure to inflammation.
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