Journal
FRONTIERS IN PEDIATRICS
Volume 2, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fped.2014.00036
Keywords
congenital diaphragmatic hernia; pulmonary hypoplasia; genetic models; teratogen; fetal lamb; fetal surgery; fetal tracheal occlusion
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In recent decades, new research into the developmental defects and pathophysiological basis of congenital diaphragmatic hernia (CDH) has revealed opportunities for the development of innovative therapies. Importantly, the use of animal models to represent this anomaly in the laboratory has resulted in the discovery of many important genetic, epigenetic, and other molecular contributors to this condition. In this review, the most commonly used and newly devised animal models of CDH are presented to familiarize the reader with the latest innovations in the basic sciences.
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