Journal
PULMONARY CIRCULATION
Volume 3, Issue 2, Pages 329-340Publisher
SAGE PUBLICATIONS INC
DOI: 10.4103/2045-8932.114760
Keywords
coagulation; microparticles; pulmonary circulation
Funding
- AHA 11 Grant [SDG7390037]
- NHLBI R03 Grant [H110828]
- NHLBI T32 Training Grant [HL076125]
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Microparticles are submicron vesicles shed from a variety of cells. Peter Wolf first identified microparticles in the midst of ongoing blood coagulation research in 1967 as a product of platelets. He termed them platelet dust. Although initially thought to be useless cellular trash, decades of research focused on the tiny vesicles have defined their roles as participators in coagulation, cellular signaling, vascular injury, and homeostasis. The purpose of this review is to highlight the science leading up to the discovery of microparticles, feature discoveries made by key contributors to the field of microparticle research, and discuss their positive and negative impact on the pulmonary circulation.
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