Journal
ROYAL SOCIETY OPEN SCIENCE
Volume 5, Issue 9, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsos.180442
Keywords
anastasis; apoptosis; mutagenesis; programmed cell death; reversal of apoptosis; reversal of cell death process
Categories
Funding
- National Cancer Institute Transition Career Development Award [CA204458]
- Hartwell Foundation Individual Biomedical Research Award
Ask authors/readers for more resources
Anastasis is a natural cell recovery phenomenon that rescues cells from the brink of death. Programmed cell death such as apoptosis has been traditionally assumed to be an intrinsically irreversible cascade that commits cells to a rapid and massive demolition. Interestingly, recent studies have demonstrated recovery of dying cells even at the late stages generally considered immutable. Here, we examine the evidence for anastasis in cultured cells and in animals, review findings illuminating the potential mechanisms of action, discuss the challenges of studying anastasis and explore new strategies to uncover the function and regulation of anastasis, the identification of which has wide-ranging physiological, pathological and therapeutic implications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available