Related references
Note: Only part of the references are listed.Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat
Garron T. Dodd et al.
CELL (2015)
Promoting Health and Longevity through Diet: From Model Organisms to Humans
Luigi Fontana et al.
CELL (2015)
SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice
Myeong Jin Yoon et al.
CELL METABOLISM (2015)
AGEs-RAGE System Down-Regulates Sirt1 Through the Ubiquitin-Proteasome Pathway to Promote FN and TGF-beta 1 Expression in Male Rat Glomerular Mesangial Cells
Kai-Peng Huang et al.
ENDOCRINOLOGY (2015)
SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1β
Seo-Hyun Cho et al.
JOURNAL OF NEUROSCIENCE (2015)
Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation
Rui Huang et al.
MOLECULAR CELL (2015)
In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences
Xiao-Hong Zhu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
SIRT1 gene variants are related to risk of childhood obesity
Ulkan Kilic et al.
EUROPEAN JOURNAL OF PEDIATRICS (2015)
The hypothalamic neural-glial network and the metabolic syndrome
Martin Jastroch et al.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM (2014)
Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence
Nady Braidy et al.
BIOGERONTOLOGY (2014)
Hypothalamic Tanycytes Are an ERK-Gated Conduit for Leptin into the Brain
Eglantine Balland et al.
CELL METABOLISM (2014)
Ubiquitin-Specific Peptidase U5P22 Negatively Regulates the STAT Signaling Pathway by Deubiquitinating SIRT1
Ning Ao et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2014)
Central Insulin Administration Improves Whole-Body Insulin Sensitivity via Hypothalamus and Parasympathetic Outputs in Men
Martin Heni et al.
DIABETES (2014)
Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice
Tsutomu Sasaki et al.
DIABETOLOGIA (2014)
Leptin and its receptors
Nobuhiro Wada et al.
JOURNAL OF CHEMICAL NEUROANATOMY (2014)
SIRT1 in Neurodevelopment and Brain Senescence
A. Zara Herskovits et al.
NEURON (2014)
Sirt1 Rescues the Obesity Induced by Insulin-Resistant Constitutively-Nuclear FoxO1 in POMC Neurons of Male Mice
Vina Yanti Susanti et al.
OBESITY (2014)
Age versus nutritional state in the development of central leptin resistance
Erika Petervari et al.
PEPTIDES (2014)
Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function
Martin Valdearcos et al.
CELL REPORTS (2014)
Insulin in the brain: its pathophysiological implications for states related with central insulin resistance, type 2 diabetes and alzheimer's disease
Enrique Blazquez et al.
FRONTIERS IN ENDOCRINOLOGY (2014)
Tanycytic VEGF-A Boosts Blood-Hypothalamus Barrier Plasticity and Access of Metabolic Signals to the Arcuate Nucleus in Response to Fasting
Fanny Langlet et al.
CELL METABOLISM (2013)
Reversal of Diet-Induced Obesity Increases Insulin Transport into Cerebrospinal Fluid and Restores Sensitivity to the Anorexic Action of Central Insulin in Male Rats
Denovan P. Begg et al.
ENDOCRINOLOGY (2013)
Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
Guo Zhang et al.
NATURE (2013)
CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age
Merly C. Vogt et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2013)
The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
Caries Canto et al.
CELL METABOLISM (2012)
Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation
Berengere Coupe et al.
CELL METABOLISM (2012)
Modulation of Leptin Resistance by Protein Tyrosine Phosphatases
Julie St-Pierre et al.
CELL METABOLISM (2012)
Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response
Wenying Quan et al.
ENDOCRINOLOGY (2012)
One Step from Prediabetes to Diabetes: Hypothalamic Inflammation?
Dongsheng Cai
ENDOCRINOLOGY (2012)
SIRT1-mediated deacetylation of MeCP2 contributes to BDNF expression
Loredana Zocchi et al.
EPIGENETICS (2012)
Obesity is associated with hypothalamic injury in rodents and humans
Joshua P. Thaler et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development
Zhenghong Lin et al.
MOLECULAR CELL (2012)
Age standardization in mapping adult overweight and obesity trends in the WHO European Region
C. M. Doak et al.
OBESITY REVIEWS (2012)
Nicotinamide Phosphoribosyltransferase May Be Involved in Age-Related Brain Diseases
Li-Ying Liu et al.
PLOS ONE (2012)
High calorie diet triggers hypothalamic angiopathy
Chun-Xia Yi et al.
MOLECULAR METABOLISM (2012)
Regulation of unfolded protein response modulator XBP1s by acetylation and deacetylation
Feng-Ming Wang et al.
BIOCHEMICAL JOURNAL (2011)
Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice
Jun Yoshino et al.
CELL METABOLISM (2011)
Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity
Hong Wang et al.
CELL METABOLISM (2011)
SIRT1 Deacetylase in SF1 Neurons Protects against Metabolic Imbalance
Giorgio Ramadori et al.
CELL METABOLISM (2011)
Deriving Ethnic-Specific BMI Cutoff Points for Assessing Diabetes Risk
Maria Chiu et al.
DIABETES CARE (2011)
Endospanins Regulate a Postinternalization Step of the Leptin Receptor Endocytic Pathway
Karin Seron et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway
Qingyuan Meng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
SIRT1 Deacetylates the DNA Methyltransferase 1 (DNMT1) Protein and Alters Its Activities
Lirong Peng et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats
M. Matheny et al.
NEUROPHARMACOLOGY (2011)
SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity
Giorgio Ramadori et al.
CELL METABOLISM (2010)
Roles of FoxO1 and Sirt1 in the central regulation of food intake
Tsutomu Sasaki et al.
ENDOCRINE JOURNAL (2010)
Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide
Tsutomu Sasaki et al.
ENDOCRINOLOGY (2010)
Differential Distribution of Tight Junction Proteins Suggests a Role for Tanycytes in Blood-Hypothalamus Barrier Regulation in the Adult Mouse Brain
Amandine Mullier et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2010)
Anorexic Vs. Metabolic Effects of Central Leptin Infusion in Rats of Various Ages and Nutritional States
Szilvia Soos et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2010)
Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity
Marcelo O. Dietrich et al.
JOURNAL OF NEUROSCIENCE (2010)
Effects of age and gender on Sirt 1 mRNA expressions in the hypothalamus of the mouse
Mathieu Lafontaine-Lacasse et al.
NEUROSCIENCE LETTERS (2010)
Effects of Obesity and Smoking on U.S. Life Expectancy
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity
Tamas L. Horvath et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Obesity and leptin resistance: distinguishing cause from effect
Martin G. Myers et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2010)
Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet
Kelly A. Posey et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2009)
MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity
Andre Kleinridders et al.
CELL METABOLISM (2009)
Endoplasmic Reticulum Stress Plays a Central Role in Development of Leptin Resistance
Lale Ozcan et al.
CELL METABOLISM (2009)
SIRT1 Genetic Variation Is Related to BMI and Risk of Obesity
M. Carola Zillikens et al.
DIABETES (2009)
Diabetes Incidence Based on Linkages With Health Plans: The Multiethnic Cohort
Gertraud Maskarinec et al.
DIABETES (2009)
Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study
S. W. van den Berg et al.
INTERNATIONAL JOURNAL OF OBESITY (2009)
The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake
Leona Plum et al.
NATURE MEDICINE (2009)
Connecting obesity, aging and diabetes
Rexford S. Ahima
NATURE MEDICINE (2009)
Hypothalamic IKKβ/NF-κB and ER stress link overnutrition to energy imbalance and obesity
Xiaoqing Zhang et al.
CELL (2008)
Association of SIRT1 gene variation with visceral obesity
Armand V. Peeters et al.
HUMAN GENETICS (2008)
Global burden of obesity in 2005 and projections to 2030
T. Kelly et al.
INTERNATIONAL JOURNAL OF OBESITY (2008)
Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice
Jennifer W. Hill et al.
JOURNAL OF CLINICAL INVESTIGATION (2008)
Megalin mediates the transport of leptin across the blood-CSF barrier
Marcelo O. Dietrich et al.
NEUROBIOLOGY OF AGING (2008)
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
In Hye Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Obese men respond to cognitive but not to catabolic brain insulin signaling
M. Hallschmid et al.
INTERNATIONAL JOURNAL OF OBESITY (2008)
The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation
Jiandi Zhang
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Nampt/PBEF/Visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme
Javier R. Revollo et al.
CELL METABOLISM (2007)
Impaired central insulin response in aged Wistar rats:: Role of adiposity
Miriam Garcia-San Frutos et al.
ENDOCRINOLOGY (2007)
SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B
Cheng Sun et al.
CELL METABOLISM (2007)
Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age
Christopher D. Morrison et al.
ENDOCRINOLOGY (2007)
Endocrine regulation of ageing
Steven J. Russell et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α
Marie Lagouge et al.
CELL (2006)
Genetics of obesity in humans
I. Sadaf Farooqi et al.
ENDOCRINE REVIEWS (2006)
Low cerebrospinal fluid insulin levels in obese humans
W. Kern et al.
DIABETOLOGIA (2006)
Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis
Min-Seon Kim et al.
NATURE NEUROSCIENCE (2006)
Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake
Tadahiro Kitamura et al.
NATURE MEDICINE (2006)
FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction
YI Kitamura et al.
CELL METABOLISM (2005)
Reduced anorexic effects of insulin in obesity-prone rats fed a moderate-fat diet
DJ Clegg et al.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2005)
Glucose transporter expression in the central nervous system: relationship to synaptic function
BS McEwen et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Insulin and the insulin receptor in experimental models of learning and memory
WQ Zhao et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
F Yeung et al.
EMBO JOURNAL (2004)
Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats
JBC Carvalheira et al.
DIABETOLOGIA (2003)
Reciprocal modulation of toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
JY Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
New criteria for 'obesity disease' in Japan
Y Matsuzawa et al.
CIRCULATION JOURNAL (2002)
β-cell function is a major contributor to oral glucose tolerance in high-risk relatives of four ethnic groups in the US
CC Jensen et al.
DIABETES (2002)
Long-term food restriction prevents ageing-associated central leptin resistance in wistar rats
C Fernández-Galaz et al.
DIABETOLOGIA (2002)
Aging is associated with resistance to effects of leptin on fat distribution and insulin action
XH Ma et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2002)
Peripheral and hypothalamic leptin resistance with age-related obesity
PJ Scarpace et al.
PHYSIOLOGY & BEHAVIOR (2001)
Decreased leptin uptake in hypothalamic nuclei with ageing in Wistar rats
C Fernández-Galaz et al.
JOURNAL OF ENDOCRINOLOGY (2001)
Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats
PJ Scarpace et al.
NEUROSCIENCE (2001)
Resistance to the anorexic and thermogenic effects of centrally administrated leptin in obese aged rats
EW Shek et al.
REGULATORY PEPTIDES (2000)
Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats
B Burguera et al.
DIABETES (2000)
Development of high fat diet-induced obesity and leptin resistance in C57BI/6J mice
S Lin et al.
INTERNATIONAL JOURNAL OF OBESITY (2000)
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
S Imai et al.
NATURE (2000)
Impaired leptin signal transduction with age-related obesity
PJ Scarpace et al.
NEUROPHARMACOLOGY (2000)
Impaired leptin responsiveness in aged rats
PJ Scarpace et al.
DIABETES (2000)
Obesity induced by a high-fat diet is associated with reduced brain insulin transport in dogs
KJ Kaiyala et al.
DIABETES (2000)
Share Paper
