Journal
INFECTION AND DRUG RESISTANCE
Volume 8, Issue -, Pages 63-74Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S49891
Keywords
hepatitis C virus; viral adaptation; immune escape; adaptive immune response
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Genetic and cellular studies have shown that the host's innate and adaptive immune responses are an important correlate of viral infection outcome. The features of the host's immune response (host resistance) reflect the coevolution between hosts and pathogens that has occurred over millennia, and that has also resulted in a number of strategies developed by viruses to improve fitness and survival within the host (viral adaptation). In this review, we discuss viral adaptation to host immune pressure via protein-protein interactions and sequence-specific mutations. Specifically, we will present the state of play on viral escape mutations to host T-cell responses in the context of the hepatitis C virus, and their influence on infection outcome.
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