Journal
INFECTION AND DRUG RESISTANCE
Volume 7, Issue -, Pages 167-176Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IDR.S48820
Keywords
gut microbiome; conjugation; natural transformation; transduction
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Funding
- Abilene Christian University
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Bacterial infections are becoming increasingly difficult to treat due to widespread antibiotic resistance among pathogens. This review aims to give an overview of the major horizontal transfer mechanisms and their evolution and then demonstrate the human lower gastrointestinal tract as an environment in which horizontal gene transfer of resistance determinants occurs. Finally, implications for antibiotic usage and the development of resistant infections and persistence of antibiotic resistance genes in populations as a result of horizontal gene transfer in the large intestine will be discussed.
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