Journal
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
Volume 1, Issue 10, Pages 844-849Publisher
WILEY-BLACKWELL
DOI: 10.1002/acn3.125
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Funding
- NIDDK NIH HHS [R01 DK064814] Funding Source: Medline
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Early diabetic neuropathy is characterized by loss of unmyelinated axons, resulting in pain, numbness, and progressive decline in intraepidermal nerve fiber density. Patients with type 2 diabetes, without neuropathy, were assigned to quarterly lifestyle counseling (N = 40) or structured, supervised weekly exercise (N = 60) for 1 year. Distal leg IENFD significantly increased in the exercise cohort and remained unchanged in the counseling cohort (1.5 +/- 3.6 vs. -0.1 +/- 3.2 fibers/mm, P = 0.03). These results suggest preclinical injury to unmyelinated axons is potentially reversible, and that IENFD may be a responsive biomarker useful in future neuropathy prevention clinical trials.
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