Journal
CANCER MANAGEMENT AND RESEARCH
Volume 7, Issue -, Pages 253-264Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/CMAR.S58285
Keywords
HIF-1; cancer; chemoresistance; signaling; apoptosis
Categories
Funding
- National Institutes of Health [RO1CA155413]
- NATIONAL CANCER INSTITUTE [R01CA155413] Funding Source: NIH RePORTER
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Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Here, we review multiple pathways regulated by hypoxia/hypoxia inducible factor 1 in cancer cells and discuss the latest advancements in overcoming hypoxia-mediated tumor resistance.
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