Journal
SCIENCE CHINA-MATERIALS
Volume 58, Issue 1, Pages 60-76Publisher
SCIENCE PRESS
DOI: 10.1007/s40843-015-0017-6
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Funding
- National Basic Research Program of China [2013CB932600]
- Major Project of International Cooperation and Exchanges [2012DFA50990]
- Program of Introducing Talents of Discipline to Universities
- National Natural Science Foundation of China [51232001, 51172022, 51372023]
- Research Fund of Co-construction Program from Beijing Municipal Commission of Education
- Fundamental Research Funds for the Central Universities
- Program for Changjiang Scholars and Innovative Research Team in University
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Biosensing has developed tremendously since it was demonstrated by Leland C. Clark Jr. in 1962. ZnO nanomaterials are attractive candidates for fabricating biosensors, because of their diverse range of nanostructures, high electron mobility, chemical stability, electrochemical activity, high isoelectric points which promote enzyme adsorption, biocompatibility, and piezoelectric properties. This review covers ZnO nanostructures applied in enzyme biosensors, in the light of electrochemical transduction and field effect transduction. Different assembly processes and immobilization methods have been used to load enzymes into various ZnO nanostructures, providing enzymes with favorable micro-environments and enhancing their sensing performance. We briefly describe recent trends in ZnO syntheses, and the analytical performance of the fabricated biosensors, summarize the advantages of using ZnO nanostructures in biosensors, and conclude with future challenges and prospects.
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