Journal
CELL SYSTEMS
Volume 7, Issue 3, Pages 245-+Publisher
CELL PRESS
DOI: 10.1016/j.cels.2018.08.003
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Funding
- National Institutes of Health [R01GM108501, T32LM012416, T32GM008136]
- BBSRC [BB/N005953/1, BB/M006484/1, BB/P010148/1] Funding Source: UKRI
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The diversity and number of species present within microbial communities create the potential for a multitude of interspecies metabolic interactions. Here, we develop, apply, and experimentally test a framework for inferringmetabolic mechanisms associated with interspecies interactions. We perform pairwise growth and metabolome profiling of co-cultures of strains from a model mouse microbiota. We then apply our framework to dissect emergent metabolic behaviors that occur in co-culture. Based on one of the inferences from this framework, we identify and interrogate an amino acid cross-feeding interaction and validate that the proposed interaction leads to a growth benefit in vitro. Our results reveal the type and extent of emergent metabolic behavior in microbial communities composed of gut microbes. We focus on growth-modulating interactions, but the framework can be applied to interspecies interactions that modulate any phenotype of interest within microbial communities.
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