Journal
CENTRAL EUROPEAN JOURNAL OF MEDICINE
Volume 3, Issue 2, Pages 123-133Publisher
DE GRUYTER POLAND SP ZOO
DOI: 10.2478/s11536-008-0002-5
Keywords
antimicrobial resistance; biosurfactants; lipopeptide antibiotics; membrane; surfactin; therapeutic agents
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Surfactin, a highly powerful biosurfactant produced by various strains of the genus Bacillus, exhibits antibacterial, antiviral, antitumor and hemolytic action. This anionic cyclic lipopeptide is constituted by a heptapeptide interlinked with a P-hydroxy fatty acid. Due to its amhipathic nature surfactin incorporates into the phospholipid bilayer and induces permeabilization and perturbation of target cells. The rising antibiotic resistance as well as a number of remarkable surfactin activities shows that it deserves special interest and is considered as a candidate compound for combating several health related issues. In this review, the current state of knowledge of surfactin properties, biomedical potential and limitations for its application is presented.
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