Journal
SPRINGERPLUS
Volume 2, Issue -, Pages -Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1186/2193-1801-2-421
Keywords
Hypusine; eIF5A; Antibody; Recombinant proteins; Cell lines
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Funding
- National Institutes of Health [R01 DK060581, T32 DK064466]
- Juvenile Diabetes Research Foundation
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [T32DK064466, R01DK060581] Funding Source: NIH RePORTER
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The translation factor eIF5A is the only protein known to contain the amino acid hypusine, which is formed posttranslationally. Hypusinated eIF5A is necessary for cellular proliferation and responses to extracellular stressors, and has been proposed as a target for pharmacologic therapy. Here, we provide the first comprehensive characterization of a novel polyclonal antibody (IU-88) that specifically recognizes the hypusinated eIF5A. IU-88 will be useful for the investigation of eIF5A biology and for the development of assays recognizing hypusinated eIF5A.
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