Journal
SKELETAL MUSCLE
Volume 4, Issue -, Pages -Publisher
BMC
DOI: 10.1186/2044-5040-4-8
Keywords
Chromatin; DMD; FSHD; Muscular dystrophy; ncRNA; Repeat
Categories
Funding
- Association Francaise contre les Myopathies (AFM)
- ERA-Net for Research on Rare Diseases (E-Rare-2)
- European Research Council (ERC)
- Italian Epigenomics Flagship Project
- Italian Ministry of Health
- FSHD Global Research Foundation
- Dulbecco Telethon Institute International postdoctoral programme (DTI-IMPORT) fellowship
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The vast majority of the mammalian genome is transcribed giving rise to many different types of noncoding RNAs. Among them, long noncoding RNAs are the most numerous and functionally versatile class. Indeed, the lncRNA repertoire might be as rich as the proteome. LncRNAs have emerged as key regulators of gene expression at multiple levels. They play important roles in the regulation of development, differentiation and maintenance of cell identity and they also contribute to disease. In this review, we present recent advances in the biology of lncRNAs in muscle development and differentiation. We will also discuss the contribution of lncRNAs to muscle disease with a particular focus on Duchenne and facioscapulohumeral muscular dystrophies.
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