Journal
SCIENTIFIC DATA
Volume 2, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sdata.2015.2
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Funding
- Defense Advanced Research Project Agency RealNose Project [R01 DC005782, R01 DC012095, R03 DC011373, R01 DC013339]
- NRSA postdoctoral fellowship [F32 DC008932]
- NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS [F32DC008932, R01DC013339, R03DC011373, R01DC005782, R01DC012095] Funding Source: NIH RePORTER
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Although the human olfactory system is capable of discriminating a vast number of odors, we do not currently understand what chemical features are encoded by olfactory receptors. In large part this is due to a paucity of data in a search space covering the interactions of hundreds of receptors with billions of odorous molecules. Of the approximately 400 intact human odorant receptors, only 10% have a published ligand. Here we used a heterologous luciferase assay to screen 73 odorants against a clone library of 511 human olfactory receptors. This dataset will allow other researchers to interrogate the combinatorial nature of olfactory coding.
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