Journal
REDOX BIOLOGY
Volume 2, Issue -, Pages 187-195Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2013.12.022
Keywords
Polyphenol; EGCG; Anti-oxidant; Pro-oxidant
Categories
Funding
- American Diabetes Association [1-09-JF-33, 1-12-BS-99, 1-13-BS-150]
- American Heart Association [13GRNT17220057]
- UAB diabetes research center - National Institutes of Health [P60 DK-079626]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK079637, P30DK072488, P30DK079626, P60DK079626] Funding Source: NIH RePORTER
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Green tea is rich in polyphenol flavonoids including catechins. Epigallocatechin 3-gallate (EGCG) is the most abundant and potent green tea catechin. EGCG has been extensively studied for its beneficial health effects as a nutriceutical agent. Based upon its chemical structure, EGCG is often classified as an antioxidant However, treatment of cells with EGCG results in production of hydrogen peroxide and hydroxyl radicals in the presence of Fe (III). Thus, EGCG functions as a pro-oxidant in some cellular contexts. Recent investigations have revealed many other direct actions of EGCG that are independent from anti-oxidative mechanisms. In this review, we discuss these novel molecular mechanisms of action for EGCG. In particular, EGCG directly interacts with proteins and phospholipids in the plasma membrane and regulates signal transduction pathways, transcription factors, DNA methylation, mitochonclrial function, and autophagy to exert many of its beneficial biological actions. (C) 2014 The Authors. Published by Elsevier B.V. All rights reserved.
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