The proteasome and the degradation of oxidized proteins: Part II - protein oxidation and proteasomal degradation

Here, we review the role of oxidative protein modification as a signal for recognition and degradation of proteins It was clearly demonstrated that the ATP- and ubiquitin-inclepenclent 20S proteasome is playing a key role in the selective removal of oxidized proteins. Furthermore, the current knowledge of the substrate susceptibility on the degradation of oxidized proteins and the role of the immunoproteasome will be highlighted. (C) 2013 The Authors. Published by Elsevier B.V.