Journal
REDOX BIOLOGY
Volume 2, Issue -, Pages 978-982Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.redox.2014.08.003
Keywords
Poly(ADP-ribosyl)ation; PARP1; Oxidative stress; Cell death; Necroptosis; Apoptosis
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Funding
- European Union
- State of Hungary
- European Social Fund [TAMOP 4.2.4.A/2-11/1-2012-0001]
- Hungarian Science Research Fund (OTKA) [K82009, K112336]
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Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly (ADP-ribose) polymerase-1 (PARR-1), part of the 17 member PARP enzyme family. PARR-1 modifies target proteins by attaching to them several NAD-derived ADP-ribose units forming poly(ADP-ribose) (PAR) polymers. PARylation controls many cellular processes while intense PARylation may also lead to cell death by various mechanisms. Here we summarize the modes of activation, inhibitors and modulators of PARR-1 and review the cellular functions regulated by the enzyme. (C) 2014 The Authors. Published by Elsevier B.V.
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