Journal
REDOX BIOLOGY
Volume 1, Issue 1, Pages 19-23Publisher
ELSEVIER
DOI: 10.1016/j.redox.2012.11.008
Keywords
Neurodegeneration; Alpha-synuclein; Lysosomes; Fission; Fusion; Reactive species; Cellular bioenergetics; Pharmacological agents
Categories
Funding
- VA merit award
- [NS064090]
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS064090] Funding Source: NIH RePORTER
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Autophagy and mitophagy are important cellular processes that are responsible for breaking down cellular contents, preserving energy and safeguarding against accumulation of damaged and aggregated biomolecules. This graphic review gives a broad summary of autophagy and discusses examples where autophagy is important in controlling protein degradation. In addition we highlight how autophagy and mitophagy are involved in the cellular responses to reactive species and mitochondrial dysfunction. The key signaling pathways for mitophagy are described in the context of bioenergetic dysfunction. (C) 2013 The Author. Published by Elsevier B.V.
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