Journal
REDOX BIOLOGY
Volume 1, Issue 1, Pages 125-130Publisher
ELSEVIER
DOI: 10.1016/j.redox.2012.12.001
Keywords
Oxysterols; Oxidative stress; Inflammation; Human chronic diseases
Categories
Funding
- Italian Ministry for the University, PRIN
- CRT Foundation, Turin
- University of Torino, Italy
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Pathological accumulation of 27-carbon intermediates or end-products of cholesterol metabolism, named oxysterols, may contribute to the onset and especially to the development of major chronic diseases in which inflammation, but also oxidative damage and to a certain extent cell death, are hallmarks and primary mechanisms of progression. Indeed, certain oxysterols exercise strong pro-oxidant and pro-inflammatory effects at concentrations detectable in the lesions typical of atherosclerosis, neurodegenerative diseases, inflammatory bowel diseases, age-related macular degeneration, and other pathological conditions characterized by altered cholesterol uptake and/or metabolism. (C) 2013 The Authors. Published by Elsevier BY. Open access under CC WI -NC-ND license.
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