Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 22, Pages 3226-3230Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00814k
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Funding
- National Natural Science Foundation of China [21502043]
- Natural Science Foundation of Shandong Province [ZR2017JL011]
- National Key Research and Development Program of China [2016YFA0501403]
- Special Funds for the Development of Strategic Emerging Industries in Shenzhen [JCYJ20170817110526264]
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The first chiral phosphoric acid catalyzed enantioselective nucleophilic addition of 5H-thiazol-4-ones to isatin-derived imines has been established. By using this strategy, the resulting 3-substituted 3-amino-2-oxindoles featuring both 5H-thiazol-4-one and vicinal sulfur-containing tetrasubstituted stereocenter structural motifs were obtained in high yields with excellent enantioselectivities and diastereoselectivities.
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