Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 19, Pages 2864-2869Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00723c
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Funding
- National Natural Science Foundation of China [21372211]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
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A novel N-iodosuccinimide-promoted intermolecular cyclization between alkenes and amidines has been demonstrated under solvent-free ball-milling conditions, affording a variety of spiroimidazolines with remarkable functional group tolerance and good to excellent yields. The present protocol features short reaction time, mild reaction conditions, high atom economy and feasibility of large-scale synthesis, providing an efficient and environmentally friendly access to spiroimidazolines.
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