Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 19, Pages 2820-2828Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00731d
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Funding
- Department of Henan Province Natural Science and Technology Foundation [172102210225]
- Natural Science Foundation in Henan Province Department of Education [17A150005, 17A150007]
- Program for Innovative Research Team from Zhengzhou [131PCXTD605]
- Project of Youth Backbone Teachers of Henan University of Technology [2016003]
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A convenient and efficient transition-metal-free protocol for the synthesis of 3-alkyl quinoxalin-2(1H)-ones from the radical reaction of quinoxalin-2(1H)-ones with ethers was developed with moderate to good yields. The methodology shows broad substrate scope, excellent functional group tolerance, high atom economy and high efficiency, thus enabling the preparation of diverse potentially valuable 3-alkyl quinoxalin-2(1H)-one derivatives.
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