Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 24, Pages -Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00727f
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Funding
- National Natural Science Foundation [21772046]
- Program of Innovative Research Team of Huaqiao University [Z14X0047]
- Recruitment Program of Global Experts (1000 Talents Plan)
- Natural Science Foundation of Fujian Province [2016J01064]
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Unprecedented quadruple cleavage of halodifluoromethyl compounds has been disclosed for the first time, resulting in carbonyl synthons for reaction with various amines. Mechanistic studies suggested that difluorocarbenes were first formed in situ between amines and halodifluoromethyl compounds, and further double C(sp(3))-F bond cleavage occurred under basic conditions, resulting in valuable formamides. Late stage modifications were successfully employed on various medicinal drugs.
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