Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 5, Issue 21, Pages 3098-3102Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8qo00805a
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Funding
- National Natural Science Foundation of China [21472057, 21572074, 21772052, 21772053]
- Natural Science Foundation of Hubei Province [2015CFA033, 2017AH047]
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1,4-Benzodioxane widely exists as the core structure in many therapeutic agents and bioactive natural compounds. Hence, to access this kind of molecule, an enantioselective desymmetric C-O cross coupling reaction has been developed through dual visible light photoredox and nickel catalysis. Notably, the use of an axially chiral 2,2-bipyridine ligand is the key to success. A series of chiral 1,4-benzodioxanes were afforded in high yields and moderate to good enantioselectivity under mild reaction conditions.
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