Journal
ORGANIC CHEMISTRY FRONTIERS
Volume 1, Issue 7, Pages 774-776Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4qo00153b
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Funding
- National Natural Science Foundation of China [21072028, 20832008]
- National Basic Research Program of China [2012CB21600]
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A convenient copper-mediated direct difluoromethylation of electron-deficient aryl iodides, as well as heteroaryl and beta-styryl iodides, using TMSCF2H has been developed. This one-step protocol proceeded at room temperature, affording various difluoromethylated products in moderate to excellent yields.
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