Trienamine catalysis with linear deconjugated 3,5-dienones

An array of deconjugated linear 3,5-dienones with substantial substitutions have been successfully used in beta, epsilon-regioselective Diels-Alder cycloadditions with 3-olefinic oxindole-based dienophiles via trienamine catalysis of cinchona-based primary amines, efficiently producing spirocyclic oxindole architectures with dense and diverse substitutions in high stereoselectivity (up to 99% ee, > 19 : 1 d.r.).