Journal
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
Volume 7, Issue 1, Pages 8-13Publisher
SCIENDO
DOI: 10.2478/s11532-008-0099-z
Keywords
Alendronate; Olpadronate, pamidronate, dissociation constant; Micellar media effect
Categories
Funding
- Ministry of Sciences and Education of Ukraine Research [0107U000659, 0106U003109]
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The dissociation constants of (4-amino-1-hydroxybutylidene)bisphosphonic (alendronic) acid, (3-(dimethylamino)-1-hydroxypropylidene)bisphosphonic (olpadronic) acid and (3-amino-1-hydroxypropylidene)bisphosphonic (pamidronic) acid were obtained in aqueous solutions (0.10 M KCl) and micellar solutions of cetylpyridinium chloride (0.10 M CPC) at 25.0A degrees C. With the exception of the third dissociation constant of alendronic acid, the dissociation constants of alendronic, olpadronic and pamidronic acids in aqueous solutions matched literature data. The possibility of sodium alendronate determination by acid-base titration by NaOH solution was theoretically grounded on the basis of re-evaluated data of alendronic acid dissociation constants.
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