Journal
CENTRAL EUROPEAN JOURNAL OF CHEMISTRY
Volume 7, Issue 1, Pages 105-110Publisher
DE GRUYTER POLAND SP ZOO
DOI: 10.2478/s11532-008-0096-2
Keywords
Schiff base; Rare earth complexes; DNA-binding studies; Antibacterial activity
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Funding
- Natural Science Foundation of Zhejiang Province, China [Y407301]
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Two novel complexes, [La(HL)(H2O)(2)NO3] center dot NO3 center dot H2O and [Gd(HL)(H2O)(2)NO3] center dot NO3 center dot H2O, where HL is a Schiff base derived from o-vanillin and lysine, have been synthesized and characterized by elemental analysis, conductivity measurements, IR, H-1 NMR and thermogravimetric analyses (TGA). The Schiff base ligand behaves as a tetradentate, coordinating through azomethine nitrogen, phenolic oxygen and two carboxylic oxygen atoms. The interaction of these complexes with calf thymus DNA (CT-DNA) was also investigated by spectrometric titration and viscometric measurements. The faint hypochromism of the complexes in the absorption spectra, the remarkable reduction of fluorescence intensity of ethidium bromide (EB) bound DNA, together with a small decrease in the viscosity of the DNA suggest that a partial intercalation may be the preferred binding mode between these two complexes and DNA. The antibacterial activity testing revealed that the complexes and their precursor Schiff base show a weak to moderate activity against Bacillus subtilis, Staphylococcus aureus and Escherichia coli.
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