Journal
ONCOIMMUNOLOGY
Volume 3, Issue 7, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.941742
Keywords
lenalidomide; pomalidomide; thalidomide; ubiquitin
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Lenalidomide and its analogs, thalidomide and pomalidomide, specifically inhibit growth of mature B-cell lymphomas, including multiple myeloma, and induce interleukin-2 (IL-2) release from T cells. We recently found that this results from activation of the CRBN-CRL4 E3 ubiquitin ligase to degrade the lymphoid transcription factors IKZF1 (Ikaros) and IKZF3 (Aiolos).
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