Journal
ONCOIMMUNOLOGY
Volume 3, Issue 5, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.28837
Keywords
photodynamic therapy; 5-aza-2 '-deoxycitidine; tumor-associated antigens; cancer; tumor immunology; methyltransferase; epigenetic
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Photodynamic therapy has been shown to induce strong immunity against tumor cells expressing exogenous tumor-associated antigens (TAAs), including P1A antigen. Cancer cells can evade the immune system by epigenetic silencing of TAAs, while DNA methyltransferase inhibitors, such as 5-aza-2'-deoxycytidine (5-aza-dC) can restore the expression of silenced or downregulated TAA. Thus, epigenetic remodeling with 5-aza-dC combined with PDT can elicit robust and durable antitumor immunity.
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