Journal
ONCOIMMUNOLOGY
Volume 3, Issue 6, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.29288
Keywords
breast cancer; PD-L1; immunotherapy; tumor infiltrating lymphocytes
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Upon analysis of 636 primary breast carcinoma patient samples, we have found that programmed cell death ligand 1 (PD-L1) mRNA expression is associated with tumor-infiltrating lymphocytes (TILs). Furthermore, PD-L1 expression and elevated TILs were associated with longer recurrence-free survival. Thus, our findings indicate that PD-L1 is prognostic in breast cancer and suggests a functional link between TILs and tumor PD-L1 upregulation.
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