Journal
ONCOIMMUNOLOGY
Volume 3, Issue 12, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.954463
Keywords
HIF-1 alpha; hypoxia; IL-10; immune suppression; MDSC; PD-L1
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Hypoxia influences immune checkpoint receptors and their respective ligands. In support, we recently demonstrated that hypoxia selectively upregulates programmed cell death ligand 1 (PD-L1) on myeloid-derived suppressor cells (MDSCs) via hypoxia inducible factor 1 alpha (HIF-1 alpha) binding to a hypoxia-response element (HRE) in the PD-L1 proximal promoter. Furthermore, blockade of PD-L1 under hypoxic conditions enhanced MDSC-mediated T-cell activation by attenuating MDSC secretion of IL-6 and IL-10.
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