Journal
ONCOIMMUNOLOGY
Volume 3, Issue 4, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.28325
Keywords
PD-L1; PI3K; triple negative breast cancer; biomarker; immunotherapy
Categories
Funding
- NCI NIH HHS [T32 CA009599] Funding Source: Medline
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Early clinical trials investigating monoclonal antibodies targeting the T-cell inhibitory receptor programmed cell death 1 (PD-1) and its ligand PD-L1 have shown efficacy in melanoma, non-small cell lung cancer and renal cell carcinoma. We recently demonstrated PD-L1 expression in 20% of triple negative breast cancers suggesting that targeting the PD-1/PD-L1 immune checkpoint may be an effective treatment modality in patients with this disease.
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