Journal
ONCOIMMUNOLOGY
Volume 3, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.27360
Keywords
difluoromethylornithine; immunomodulation; polyamines; transport inhibitor; tumor microenvironment
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Funding
- NATIONAL CANCER INSTITUTE [P30CA056036] Funding Source: NIH RePORTER
- NCI NIH HHS [P30 CA056036] Funding Source: Medline
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The levels of polyamines are elevated in neoplastic lesions as compared with normal tissues, and cancer cells tend to manifest a robust dependence on these compounds for proliferation and survival. We have recently demonstrated that a novel approach to polyamine depletion suppresses tumor growth in a T cell-dependent manner, highlighting a poorly appreciated role of polyamines as strong modulators of antitumor immune responses.
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