Journal
ONCOIMMUNOLOGY
Volume 3, Issue 8, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.954832
Keywords
dendritic cells; immunotherapy; vaccine
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Targeting antigens directly to dendritic cells (DCs) in situ has emerged as a promising strategy to potentiate immunity. A recent clinical trial of antibody-mediated targeting of tumor antigen NY-ESO1 to the DC receptor DEC-205 demonstrated an induction of strong cellular and humoral responses. Recent studies with DC-targeting via nanoparticles suggest that combinatorial targeting of multiple human DC subsets may further improve the efficacy of DC targeting.
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