Journal
ONCOIMMUNOLOGY
Volume 3, Issue 1, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.27218
Keywords
cancer stem cells; glioma; herpes simplex virus; interleukin-12; oncolytic virus; Treg
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Funding
- NCI NIH HHS [R01 CA160762] Funding Source: Medline
- NINDS NIH HHS [R01 NS032677] Funding Source: Medline
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We have recently described a new murine model of glioblastoma, generated by the implantation of syngeneic glioblastoma stem cells into immunocompetent mice, that recapitulates the salient histopathological and immunological features of the human disease. We employed this model to demonstrate the multifaceted activity of an oncolytic herpes simplex virus genetically modified to express interleukin-12, G47 Delta-IL12.
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