Journal
ONCOIMMUNOLOGY
Volume 3, Issue 7, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/21624011.2014.944059
Keywords
adoptive cell therapy; cancer immunology; chimeric antigen receptor; gene-engineering; glioblastoma; tumor immunotherapy
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Funding
- NCI NIH HHS [DP2 CA174502] Funding Source: Medline
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CAR therapy has shown promise in treating cancer, but at the cost of unexpected toxicity against normal tissues, not predicted by preclinical testing. We are working to generate more physiologically relevant models for preclinical CAR toxicity testing, and in doing so, have discovered that CAR therapy induces immunogenic cell death, with the potential for cures.
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