Journal
ONCOIMMUNOLOGY
Volume 3, Issue 1, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.27659
Keywords
colon cancer; grp94; gp96; inflammation; TLR; tumor-associated macrophages
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It is unclear how tumor-associated macrophages (TAMs) contribute to the initiation of oncogenesis and how they are regulated at the molecular level. By using a lineage-specific deletion strategy, we found that heat shock protein 90kDa beta (Grp94), member 1 (HSP90B1), a master chaperone for Toll-like receptors and integrins also known as GP96, critically endows TAMs with the ability to promote genotoxic stress and colitis-associated colon cancer.
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