Journal
ONCOIMMUNOLOGY
Volume 3, Issue 4, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.28540
Keywords
electropermeabilization; electric pulses; gene electrotransfer; non-viral gene therapy; immunotherapy; dendritic cell; T lymphocyte; ATP; DAMPs
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Funding
- CNRS
- University of Paris-Sud
- Gustave Roussy
- Fondation EDF
- Departement du Valde-Marne through the TELVAC project
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DNA vaccination consists of administering an antigen-coding nucleotide sequence. In order to improve the efficacy of DNA vaccines, electroporation is one of the most commonly used methods to enhance DNA uptake. Here, we discuss additional immunological effects of electroporation that are key aspects for inducing immunity in response to DNA vaccines.
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