Journal
ONCOIMMUNOLOGY
Volume 3, Issue 9, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/21624011.2014.955441
Keywords
CDK8; immunotherapy; NK cells; STAT1; tumor immune surveillance
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Serine phosphorylation has generally been considered indispensable for full transcriptional activity of STAT proteins. Recent data indicate that CDK8-mediated phosphorylation of signal transducer and activator of transcription 1 (STAT1) on S727 inhibits natural killer (NK) cell cytotoxicity and restrains tumor surveillance. These findings implicate CDK8 as a promising target for immunotherapy.
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