Journal
ONCOIMMUNOLOGY
Volume 3, Issue 2, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.27989
Keywords
A2bR; immunosuppression; immunotherapy; MDSCs; tumor microenvironment
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Emerging evidence suggests that the adenosine A2b receptor (ADORA 2B, also known as A2bR) plays a pivotal role in tumor progression. We have recently demonstrated that blocking A2bR stimulates T cell-mediated immunosurveillance in a melanoma model by impairing the influx of myeloid-deriver suppressor cells (MDSCs) into the tumor microenvironment. This results in robust antineoplastic effects, which can be abrogated by the adoptive transfer of MDSCs.
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