Journal
ONCOIMMUNOLOGY
Volume 3, Issue 3, Pages -Publisher
LANDES BIOSCIENCE
DOI: 10.4161/onci.28326
Keywords
sleep fragmentation; macrophage polarity; sleep apnea; angiogenesis; intermittent hypoxia; invasion
Categories
Funding
- National Institutes of Health [HL-65270, HL-086662, HL-107160]
- Beatriu de Pinos fellowship from Generalitat de Catalunya [2010 BP_A 00238]
Ask authors/readers for more resources
The presence of obstructive sleep apnea (OSA) in patients with cancer appears to be accompanied by poorer outcomes. However, the mechanisms underlying such association are unknown. We hypothesize that the constitutive characteristics of OS A, namely, intermittent hypoxia and sleep fragmentation, promote changes in the tumor microenvironment that ultimately lead to a disadvantageous immunosurveillance, thereby accelerating tumor proliferation and enhancing its invasiveness.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
