Journal
ONCOIMMUNOLOGY
Volume 3, Issue 3, Pages -Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.28223
Keywords
Ontak; dendritic cells; T cells; regulatory T cells; interleukin-2 receptor
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Ontak (R), a conjugate between IL-2 and a diphtheria toxin fragment, was recently investigated in cancer clinical trials aiming to kill CD25(+) regulatory T cells (T-regs). We found that the activity of Ontak (R) was more complex on T-regs and conventional T cells (T-convs) than anticipated, including a novel strong influence on dendritic cells (DCs).
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